Soma (carisoprodol) Disease Interactions
There are 3 disease interactions with Soma (carisoprodol):
Carisoprodol (Includes Soma) ↔ Porphyria
Severe Potential Hazard, High plausibility
Applies to: Porphyria
The use of carisoprodol is contraindicated in patients with acute intermittent porphyria. Carisoprodol is partially metabolized to the pharmacologically active meprobamate, which has been reported to precipitate acute attacks of porphyria in susceptible patients.
Carisoprodol (Includes Soma) ↔ Drug Dependence
Moderate Potential Hazard, Moderate plausibility
Applies to: Alcoholism, Drug Abuse/Dependence
Carisoprodol is partially metabolized to meprobamate, a pharmacologically active agent with known addictive potential. According to the manufacturer, abrupt cessation of carisoprodol 100 mg/kg/day (approximately 5 times the recommended daily adult dosage) was associated with mild withdrawal symptoms such as abdominal cramps, insomnia, headache, nausea and chills in some study subjects. In clinical use, psychological dependence and abuse have been rare. Nevertheless, therapy with carisoprodol should be administered cautiously in addiction-prone individuals, such as those with a history of alcohol or substance abuse. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Carisoprodol (Includes Soma) ↔ Renal/Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Liver Disease, Renal Dysfunction
Carisoprodol is primarily converted in the liver to several metabolites, one of which (meprobamate) is pharmacologically active. The metabolites and a small amount of the parent drug are excreted in the urine. Patients with impaired renal and/or hepatic function may be at greater risk for adverse effects due to drug and metabolite accumulation. Therapy with carisoprodol should be administered cautiously in such patients.
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Soma (carisoprodol) drug Interactions
There are 648 drug interactions with Soma (carisoprodol)
Soma (carisoprodol) alcohol/food Interactions
There is 1 alcohol/food interaction with Soma (carisoprodol)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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