BuSpar (buspirone) Disease Interactions
There are 2 disease interactions with BuSpar (buspirone):
Buspirone (Includes BuSpar) ↔ Renal/Liver Disease
Severe Potential Hazard, High plausibility
Applies to: Liver Disease, Renal Dysfunction
Buspirone is primarily metabolized by the liver and subsequently eliminated by the kidney. In one study, steady-state area under the plasma concentration-time curve (AUC) of buspirone increased 13-fold in subjects with hepatic impairment and 4-fold in those with renal impairment compared to healthy subjects. Therapy with buspirone is not recommended in the presence of significantly impaired hepatic or renal function.
Buspirone (Includes BuSpar) ↔ Drug Dependence
Moderate Potential Hazard, Low plausibility
Applies to: Drug Abuse/Dependence, Alcoholism
In human and animal studies, buspirone has not shown potential for abuse or diversion, and there is no evidence that it causes tolerance or physical and psychological dependence. However, since it is a CNS-active drug, the manufacturers recommend that therapy with buspirone be administered cautiously in addiction-prone individuals, such as those with a history of alcohol or substance abuse. It may be prudent to refrain from dispensing large quantities of medication to these patients.
You should also know about...
BuSpar (buspirone) drug Interactions
There are 702 drug interactions with BuSpar (buspirone)
BuSpar (buspirone) alcohol/food Interactions
There are 2 alcohol/food interactions with BuSpar (buspirone)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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