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Baclofen Disease Interactions

There are 4 disease interactions with baclofen:

Baclofen (Includes Baclofen) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Baclofen is primarily eliminated by the kidney. Patients with impaired renal function may be at greater risk for adverse effects from baclofen due to decreased drug clearance. Therapy with baclofen should be administered cautiously in such patients. Dosage adjustments may be necessary.

References

  1. Himmelsbach FA, Kohler E, Zanker B "Toxic effect of baclofen in chronic haemodialysis and renal transplantation." Dtsch Med Wochenschr 117 (1992): 733-7
  2. Krahn A, Penner SB "Use of baclofen for intractable hiccups in uremia." Am J Med 96 (1994): 391
  3. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.

Baclofen (Includes Baclofen) ↔ Autonomic Dysreflexia

Moderate Potential Hazard, Moderate plausibility

Applies to: Autonomic Dysreflexia

Therapy with intrathecal baclofen should be administered cautiously in patients with a history of autonomic dysreflexia, since the presence of nociceptive stimuli or abrupt withdrawal of the medication may trigger an episode of dysreflexia.

References

  1. "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Inc, Minneapolis, MN.

Baclofen (Includes Baclofen) ↔ Psychoses

Moderate Potential Hazard, Moderate plausibility

Applies to: Psychosis, History - Psychiatric Disorder

Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.

References

  1. Sommer BR, Petrides G "A case of baclofen-induced psychotic depression." J Clin Psychiatry 53 (1992): 211-2
  2. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.
  3. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
View all 15 references

Baclofen (Includes Baclofen) ↔ Seizure Disorders

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Therapy with baclofen should be administered cautiously in patients with a history of seizures. Clinical status and EEG should be monitored at regular intervals during treatment. Except in cases of overdose or severe adverse reactions, cessation of baclofen therapy, whenever necessary, should occur gradually with incrementally reduced dosages. Abrupt withdrawal has been associated with central nervous system effects including seizures, hallucinations, and psychosis.

References

  1. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.
  2. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  3. Kirubakaran V, Mayfield D, Rengachary S "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry 141 (1984): 692-3
View all 15 references

You should also know about...

baclofen drug Interactions

There are 706 drug interactions with baclofen

baclofen alcohol/food Interactions

There is 1 alcohol/food interaction with baclofen

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2014 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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