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Pronunciation: wĕr′nĕr
Definition: a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.
Examples: glitazone, GI cocktail, etc.
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