Definition: The chief end product of nitrogen metabolism in mammals, formed in the liver by means of the Krebs-Henseleit cycle and excreted in normal adult human urine in the amount of about 32 g a day (about 85% of the nitrogen excreted from the body). It may be obtained artificially by heating a solution of ammonium cyanate. It occurs as colorless or white prismatic crystals, without odor but with a cooling saline taste, is soluble in water, and forms salts with acids; has been used as a diuretic in kidney function tests, and topically for various dermatitides.
[G. ouron, urine]
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Examples: glitazone, GI cocktail, etc.