Medical Term:

sphingomyelin phosphodiesterase

Pronunciation: sfing′gō-mī′ĕ-lin fos′fō-dī-es′tĕr-ās

Definition: An enzyme catalyzing hydrolysis of sphingomyelin to N-acylsphingosine (a ceramide) and phosphocholine; a deficiency of this enzyme is associated with type I Niemann-Pick disease.

Synonym(s): sphingomyelinase

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Examples: glitazone, GI cocktail, etc.

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