Definition: Thickening and induration of the skin caused by new collagen formation, with atrophy of pilosebaceous follicles; either a manifestation of progressive systemic sclerosis or localized (morphea).
Synonym(s): systemic scleroderma, systemic sclerosis2
[sclero- + G. derma, skin]
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.