primary biliary cirrhosis
Definition: a condition occurring mainly in middle-aged women, characterized by cholestasis with hyperlipemia, pruritus, and hyperpigmentation of the skin; no obstruction of large bile ducts or proliferation of small bile ducts is found; the liver shows cirrhosis with marked portal infiltration by lymphocytes and plasma cells, and frequently by epithelioid cell granulomas; serum antimitochondrial antibodies are present in 85–90% of patients.
Synonym(s): Hanot cirrhosis
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Examples: glitazone, GI cocktail, etc.