Medical Term:

phosphoribosyltransferase

Pronunciation: fos′fō-rī′bō-sil-trans′fĕr-ās

Definition: One of a group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d-ribose 5-phosphate from 5-phospho-α-d-ribosyl pyrophosphate to a purine, pyrimidine, or pyridine acceptor, forming a 5′-nucleotide and pyrophosphate, or d-ribose from d-ribosyl phosphate to a base, forming a nucleoside, or similar pentose transfers; important in nucleotide biosynthesis. Specific phosphoribosyltransferases are preceded by the name of the acceptor base, uracil phosphoribosyltransferase (uracil + PRPP ⇋ UMP + pyrophosphate).

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