Definition: a scheme for substrate binding and product release for multisubstrate enzymes; for a two-substrate two-product enzyme with an ordered mechanism, one particular substrate has to first bind to the enzyme, followed by the other substrate; chemistry then occurs, and products are formed and are released from the enzyme in a distinct order. More complex ordered schemes exist for enzymes having more than two substrates. Some dehydrogenases have such a mechanism.
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Examples: glitazone, GI cocktail, etc.