Pronunciation: mi-kā′lis men′tĕn
Definition: an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration; v = Vmax [S]/(Km + [S]), where v is the initial velocity of the reaction, Vmax is the maximum velocity, [S] is the initial substrate concentration, and Km is the Michaelis constant. Similar equations can be derived for conditions in which the product is present and for multisubstrate enzymes.
Synonym(s): Henri-Michaelis-Menten equation
[Leonor michaelis, Maud L. Menten]
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.