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Medical Term:


Pronunciation: mel′ăn-kō′lē-ă


  1. A severe form of depression marked by anhedonia, insomnia, psychomotor changes, and guilt.
  2. A symptom occurring in other conditions, marked by depression of spirits and by a sluggish and painful process of thought.

Synonym(s): melancholy

[melan- + G. cholē, bile. See humoral doctrine]