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Definition: the limes nul dose of diphtheria toxin, the largest amount of toxin that, when mixed with one unit of antitoxin and injected subcutaneously into a 250-g guinea pig, yields no recognizable reaction in the average of a series; actually, the Lod. is usually recorded as the one that causes a barely perceptible local edema at the site of inoculation.
Examples: glitazone, GI cocktail, etc.
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