Medical Term:

leukoencephalopathy

Pronunciation: lū′kō-en-sef′ă-lop′ă-thē

Definition: White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.

[leuko- + G. enkephalos, brain, + pathos, suffering]

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