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Definition: an autosomal dominant trait, with onset in childhood of scales on the trunk and extremities but not on the flexural areas, and associated with atopy and prominent palmar and plantar markings; histologically, there are hyperkeratosis, absence of a granular layer in the epidermis, and normal epidermal cell turnover.
Synonym(s): hyperkeratosis congenita, ichthyosis simplex
Examples: glitazone, GI cocktail, etc.
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