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Definition: vacuolation of the epithelial cytoplasm of renal convoluted tubules in people seriously depleted of potassium; vacuoles do not contain fat or glycogen, concentrating ability is impaired, polyuria and polydipsia are common, and pyelonephritis may develop.
Synonym(s): vacuolar nephrosis
Examples: glitazone, GI cocktail, etc.
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