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Pronunciation: hol′ō sin′thās
Definition: An enzyme that catalyzes transfer of the 4′-phosphopantetheinyl residue from coenzyme A to a seryl residue of apo-ACP (acyl-carrier protein) to form holo-ACP, releasing adenosine 3′,5′-bisphosphate; a required step if fatty acid biosynthesis is to function.
Examples: glitazone, GI cocktail, etc.
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