Definition: a cell-mediated response that occurs in immune people peaking at 24–48 hours after challenge with the same antigen used in an initial challenge. The interaction of T-helper 1 (Th-1) lymphocytes with MHC class II positive antigen-presenting cells initiates the response. This interaction induces the Th-1s and macrophages at the site to secrete cytokines, which are the major factors in the reaction. Called tuberculin-type hypersensitivity.
Synonym(s): cell-mediated immunity
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