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Definition: specifically, the massive bundle of corticofugal nerve fibers passing longitudinally on the ventral surface of the midbrain on each side of the midline; it consists of fibers descending from the cortex to the tegmentum of the brainstem, pontine gray matter, and spinal cord.
See Also: cerebral peduncle, basis pedunculi
Examples: glitazone, GI cocktail, etc.
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