Crooke hyaline change
Pronunciation: kruk
Definition: replacement of cytoplasmic granules of basophil cells of the anterior pituitary by homogeneous hyaline material; a characteristic finding in Cushing syndrome, but usually not present in the cells of a basophil adenoma.
Synonym(s): Crooke hyaline degeneration
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Examples: glitazone, GI cocktail, etc.
