corepressor
Pronunciation: kō′rē-pres′ŏr
Definition: A molecule, usually a product of a specific metabolic pathway (nuclear protein), which combines with and activates a repressor produced by a regulator gene. The activated repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism negatively regulates enzyme production in repressible enzyme systems.
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Examples: glitazone, GI cocktail, etc.
