Medical Term:

coregulators

Pronunciation: kō′reg′yū-lā-tŏrz

Definition: Nuclear proteins that participate in the regulation of transcription of genes that are responsive to ligand-dependent transcription factors. Distinguished loosely into coactivators or corepressors depending on the direction of coregulation. Defective coregulators have been associated with human disease.

[co- + regulator]

See Also: coactivator, corepressors

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Examples: glitazone, GI cocktail, etc.

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