Definition: a zinc-containing enzyme that catalyzes the interconversion of CO2 with HCO3− and H+. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma.
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Examples: glitazone, GI cocktail, etc.