Definition: A small, ubiquitous eukaryotic protein that binds calcium ions, thereby becoming the agent for many of the cellular effects long ascribed to calcium ions. This calcium-protein complex binds to the apoenzyme, to form the holoenzyme, of certain phosphodiesterases; through these mechanisms, the complex regulates adenylate and guanylate cyclases, many kinases, phospholipase A2 activity, and other basic cellular functions.
[calcium + modulate]
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Examples: glitazone, GI cocktail, etc.