basal cell nevus
Definition: a hereditary disease noted in infancy or adolescence, characterized by lesions of the eyelids, nose, cheeks, neck, and axillae, appearing as uneroded flesh-colored papules, some becoming pedunculated, and histologically indistinguishable from basal cell epithelioma; also noted are punctate keratotic lesions of the palms and soles; the lesions usually remain benign, but in some cases ulceration and invasion occur and are evidence of malignant change; autosomal dominant inheritance; caused by mutation in the human PTCH, the homologue of the “patched gene” of Drosophila. PTCH is found on chromosome 9q22.
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