Pronunciation: ă′ris-tō-lō′kik as′idz
Definition: Aromatic mixtures of nitrophenanthrene derivatives from plants of the genus Aristolochia. Some are components of various Chinese herbal medications, known to cause interstitial renal fibrosis that can progress to end-stage renal disease (ESRD) even after discontinuation of intake. Some are potent carcinogens, employed in animal and bacterial studies. Human urothelial carcinomas can result from their use.