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Definition: surface receptors on immune cells, which participate in cell-cell interactions and modulate the immunologic outcome. For example, in T-cell recognition of B-cell presented–antigen, the primary interaction occurs through CD3-CD4 binding to MHC and antigen, but this interaction is amplified if concomitant accessory molecule binding also occurs, CD28 to B7.
Examples: glitazone, GI cocktail, etc.
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