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Viracept

Generic name: nelfinavirnel-FIN-a-veer ]
Drug class: Protease inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 13, 2023.

What is Viracept?

Viracept is an antiviral medicine that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Viracept is used to treat HIV (human immunodeficiency virus). HIV can cause acquired immunodeficiency syndrome (AIDS).

Viracept is not a cure for HIV or AIDS.

Viracept is for use in adults and children at least 2 years old.

Warnings

You should not use Viracept if you have moderate to severe liver disease.

Life-threatening side effects may occur if you take Viracept with alfuzosin (Uroxatral), amiodarone (Cordarone, Pacerone), lovastatin (Mevacor, Altoprev, Advicor), midazolam (Versed), quinidine (Quin-G), pimozide (Orap), rifampin (Rifadin, Rimactane, Rifater), sildenafil (Revatio for pulmonary arterial hypertension), simvastatin (Zocor, Simcor, Vytorin, Juvisync), St. John's wort, triazolam (Halcion), or an ergot medicine such as Ergomar, Ergotrate, Cafergot, Wigraine, D.H.E. 45, Migranal, or Methergine.

Taking Viracept will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Before taking this medicine

You should not use Viracept if you are allergic to nelfinavir, or if you have moderate or severe liver disease.

Some drugs should not be used with Viracept. Your treatment plan may change if you also use:

To make sure Viracept is safe for you, tell your doctor if you have:

Viracept oral powder contains phenylalanine and could be harmful if you have phenylketonuria (PKU).

To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry.

Viracept can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. Use barrier birth control to prevent pregnancy: condom, diaphragm, cervical cap, or contraceptive sponge.

Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk.

How should I take Viracept?

Take Viracept exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Take Viracept with food.

Swallow the tablet whole.

If you cannot swallow a whole Viracept tablet, dissolve it in a small amount of water. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away.

Mix the oral powder in a cup with a small amount of water, milk, baby formula, soy milk, or a liquid dietary supplement. To avoid bitter taste, do not mix the powder with acidic liquids such as orange juice, apple juice, or applesauce.

Drink all of the mixed powder right away. If a child taking this medicine doesn't finish the entire dose, you may store the mixture in a refrigerator for up to 6 hours.

Nelfinavir doses are based on weight in children. Your child's dose may change if the child gains or loses weight.

Use all HIV medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Remain under the care of a doctor.

You will need frequent medical tests.

Store Viracept at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for HIV Infection:

1250 mg orally twice a day or 750 mg orally 3 times a day

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure:

US CDC recommendations: 1250 mg orally twice a day or 750 mg orally 3 times a day
Duration of therapy: 28 days

Comments:
-Recommended as part of an alternative regimen for nonoccupational postexposure prophylaxis of HIV infection
-This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or stavudine or abacavir or tenofovir or didanosine).
-Prophylaxis should be started as soon as possible, within 72 hours of exposure.
-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for HIV Infection:

2 to less than 13 years: 45 to 55 mg/kg orally twice a day or 25 to 35 mg/kg orally 3 times a day
Maximum dose: 2500 mg/day

-Oral powder (50 mg/g):
9 to less than 10.5 kg: 500 mg orally twice a day or 300 mg orally 3 times a day
10.5 to less than 12 kg: 550 mg orally twice a day or 350 mg orally 3 times a day
12 to less than 14 kg: 650 mg orally twice a day or 400 mg orally 3 times a day
14 to less than 16 kg: 750 mg orally twice a day or 450 mg orally 3 times a day
16 to less than 18 kg: 500 mg orally 3 times a day
18 to less than 23 kg: 600 mg orally 3 times a day
23 kg or more: 750 mg orally 3 times a day

-Tablets (250 mg):
10 to 12 kg: 500 mg orally twice a day or 250 mg orally 3 times a day
13 to 18 kg: 750 mg orally twice a day or 500 mg orally 3 times a day
19 to 20 kg: 1000 mg orally twice a day or 500 mg orally 3 times a day
21 kg or more: 1000 to 1250 mg orally twice a day or 750 mg orally 3 times a day

13 years or older:
-Tablets: 1250 mg orally twice a day or 750 mg orally 3 times a day

Comments: For twice-daily dosing, the 250 mg tablets are recommended for children weighing 16 kg or more.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

What happens if I miss a dose?

Take Viracept as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Viracept?

Using Viracept will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe.

Viracept side effects

Get emergency medical help if you have signs of an allergic reaction to Viracept: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Nelfinavir can affect your immune system (even weeks or months after you've used this medicine). Tell your doctor if you have:

Common Viracept side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Viracept?

If you also take didanosine, take your Viracept dose (with food) 1 hour after or more than 2 hours before you take didanosine.

Many drugs can interact with nelfinavir, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Viracept only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.