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Trelstar LA

Generic Name: triptorelin (Intramuscular route)

trip-toe-REL-in

Commonly used brand name(s)

In the U.S.

  • Trelstar
  • Trelstar Depot
  • Trelstar LA

Available Dosage Forms:

  • Powder for Suspension

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Luteinizing Hormone Releasing Hormone Agonist

Uses For Trelstar LA

Triptorelin is used to treat advanced prostate cancer in men. It is a hormone that is similar to the one normally released from the hypothalamus gland in the brain. When given on a regular basis to men, triptorelin decreases testosterone levels which helps treat prostate cancer.

Slideshow: Flashback: FDA Drug Approvals 2013

This medicine is to be given only by or under the supervision of a doctor.

Before Using Trelstar LA

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of triptorelin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triptorelin in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters X Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bladder blockage or
  • Diabetes or
  • Heart or blood vessel disease or
  • Hyperglycemia (high blood sugar) or
  • Spinal cord problems—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of triptorelin

This section provides information on the proper use of a number of products that contain triptorelin. It may not be specific to Trelstar LA. Please read with care.

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into your muscle (usually in the buttocks). This medicine needs to be given on a fixed schedule. Make sure you keep all of your appointments.

Precautions While Using Trelstar LA

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive the medicine.

When you first start using this medicine, some of your symptoms might get worse or you might have new symptoms for a short time. Tell your doctor right away if you have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.

This medicine may cause changes in your blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.

This medicine may increase your risk of having a heart attack or stroke. Call your doctor right away if you have chest pain or discomfort; pain or discomfort in the arms, jaw, back, or neck; shortness of breath; nausea; sweating; or vomiting.

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Trelstar LA Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • burning while urinating
  • chest pain
  • cough producing mucus
  • decrease in urine volume or frequency of urination
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • difficulty in passing urine
  • dizziness
  • dry mouth
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • high blood pressure
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • lower back or side pain
  • nausea
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • shortness of breath
  • slow or fast heartbeat
  • stomachache
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing
  • troubled breathing with exertion
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • wheezing
Incidence not known
  • Anxiety
  • changes in skin color
  • changes in vision
  • chest discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness or lightheadedness
  • fainting
  • inability to speak
  • irregular heartbeats
  • numbness or tingling in the face, arms, or legs
  • pain
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, redness, or swelling in the arm or leg
  • seizures
  • severe or sudden headache
  • slow heart rate
  • slurred speech
  • sudden shortness of breath or troubled breathing
  • temporary blindness
  • tenderness
  • trouble speaking, thinking, or walking
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bone pain
  • chills
  • decrease in testicle size
  • diarrhea
  • fever
  • decreased interest in sexual intercourse
  • feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  • general feeling of discomfort or illness
  • inability to have or keep an erection
  • joint pain
  • leg pain
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • muscle aches and pains
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • shivering
  • sore throat
  • sudden sweating
  • trouble sleeping
Less common
  • Acid or sour stomach
  • back pain
  • belching
  • body aches or pain
  • breast pain
  • burning, dry, or itching eyes
  • congestion
  • crying
  • depersonalization
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • discharge or excessive tearing
  • dysphoria
  • euphoria
  • eye pain
  • heartburn
  • hoarseness
  • indigestion
  • injection site pain
  • itching
  • lack or loss of strength
  • leg cramps
  • loss of appetite
  • mental depression
  • muscle aching or cramping
  • muscle pains or stiffness
  • pain
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • rash
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sleeplessness
  • stomach discomfort, upset, or pain
  • swelling of the breasts or breast soreness in both females and males
  • swollen joints
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
  • weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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