Generic Name: trimethobenzamide (Oral route)

trye-meth-oh-BENZ-a-mide

Commonly used brand name(s)

In the U.S.

  • Tigan

Available Dosage Forms:

  • Capsule

Therapeutic Class: Antiemetic

Pharmacologic Class: Anticholinergic

Uses For Tigan

Trimethobenzamide is used to treat nausea and vomiting .

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This medicine is available only with your doctor's prescription .

Before Using Tigan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of trimethobenzamide in the pediatric population. However, because of this medication's toxicity, use in children is not recommended. Safety and efficacy have not been established .

Geriatric

Appropriate studies on the relationship of age to the effects of trimethobenzamide have not been performed in the geriatric population. However, elderly patients are more likely to have age-related kidney disease, which may require an adjustment of dosage in patients receiving trimethobenzamide .

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Metoclopramide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Dehydration or
  • Electrolyte imbalance (high or low levels of minerals in the blood) or
  • High fever or
  • Intestinal infection, severe—May cause side effects to become worse .
  • Kidney disease—Use with caution. The effects of this medicine may be increased because of slower removal from the body .

Proper Use of Tigan

Do not use this medicine to treat nausea and vomiting in children unless otherwise directed by your doctor. If you are giving this medicine to a child, be very careful not to give more than your doctor ordered. The side effects of this medicine may be more serious in children .

Trimethobenzamide is only used to relieve or prevent nausea and vomiting. Use it as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of side effects .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For nausea and vomiting:
      • Adults—300 milligrams (mg) three or four times a day as needed.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Tigan

Trimethobenzamide will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide .

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert .

Tigan Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Body spasm, with head and heels bent backward and body bowed forward
  • convulsions (seizures)
  • depression
  • shakiness or tremors
  • skin rash
  • sore throat or fever
  • unusual tiredness
  • vomiting (severe or continuing)
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Drowsiness
Less common
  • Blurred vision
  • diarrhea
  • dizziness
  • headache
  • muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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