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thiabendazole (Topical route)

thye-a-BEN-da-zole

Chemical Class: Benzimidazole

Uses For thiabendazole

Thiabendazole belongs to the family of medicines called anthelmintics. Anthelmintics are medicines used in the treatment of worm infections.

Thiabendazole topical preparations are used to treat a skin disease called cutaneous larva migrans (creeping eruption). Cutaneous larva migrans is caused by dog and cat hookworm larvae. These larvae cause slowly moving burrows or tunnels in the skin. This may result in itching, redness, or inflammation around the end of the burrows or tunnels.

Thiabendazole is available only with your doctor's prescription.

Before Using thiabendazole

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For thiabendazole, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to thiabendazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing the use of thiabendazole in children with use in other age groups, thiabendazole is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people, Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of thiabendazole in the elderly with use in other age groups, thiabendazole is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking thiabendazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using thiabendazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of thiabendazole

Apply thiabendazole directly to, and about 5 to 7.5 cm (2 to 3 inches) around, the slowly moving end of each burrow or tunnel being made by the larva of the worm in the skin.

To help clear up your infection completely, use thiabendazole exactly as directed by your doctor for the full time of treatment . Do not miss any doses.

Dosing

The dose of thiabendazole will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of thiabendazole. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (suspension):
    • For cutaneous larva migrans:
      • Adults and children—Use two to four times a day for two to seven days.

Missed Dose

If you miss a dose of thiabendazole, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using thiabendazole

If your skin problem does not improve within a few days, or if the burrow or tunnel continues to get longer, check with your doctor.

thiabendazole Side Effects

There have not been any common or important side effects reported with thiabendazole when used on the skin. However, if you notice any side effects, check with your doctor.

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