rifapentine (Oral route)

rif-a-PEN-teen

Commonly used brand name(s)

In the U.S.

  • Priftin

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antitubercular

Chemical Class: Rifamycin

Uses For rifapentine

Rifapentine is used with other medicines to treat tuberculosis.

To help clear up your tuberculosis completely, you must keep taking rifapentine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

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Rifapentine is available only with your doctor's prescription.

Before Using rifapentine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifapentine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to rifapentine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Safety and efficacy have not been established in infants and children younger than 12 years of age. For children 12 years of age and older, rifapentine is not expected to cause different side effects or problems than it does in adults.

Geriatric

Rifapentine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rifapentine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using rifapentine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Artemether
  • Lurasidone
  • Maraviroc
  • Ranolazine
  • Rilpivirine

Using rifapentine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Amprenavir
  • Apremilast
  • Atazanavir
  • Axitinib
  • Bedaquiline
  • Bortezomib
  • Bosutinib
  • Cabazitaxel
  • Cabozantinib
  • Clozapine
  • Cobicistat
  • Dabrafenib
  • Darunavir
  • Dolutegravir
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Efavirenz
  • Elvitegravir
  • Enzalutamide
  • Erlotinib
  • Etravirine
  • Everolimus
  • Fentanyl
  • Fosamprenavir
  • Hydrocodone
  • Ibrutinib
  • Indinavir
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Lopinavir
  • Macitentan
  • Mifepristone
  • Nelfinavir
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Pazopanib
  • Perampanel
  • Piperaquine
  • Pomalidomide
  • Ponatinib
  • Quetiapine
  • Regorafenib
  • Ritonavir
  • Rivaroxaban
  • Romidepsin
  • Saquinavir
  • Simeprevir
  • Sofosbuvir
  • Sunitinib
  • Tasimelteon
  • Ticagrelor
  • Tipranavir
  • Tofacitinib
  • Tolvaptan
  • Trabectedin
  • Vandetanib
  • Vemurafenib
  • Vilazodone
  • Vincristine Sulfate
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Vortioxetine

Using rifapentine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Acetyldigoxin
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Betamethasone
  • Bisoprolol
  • Carbamazepine
  • Carteolol
  • Carvedilol
  • Chloramphenicol
  • Chlorpropamide
  • Ciprofloxacin
  • Clarithromycin
  • Clofibrate
  • Cyclosporine
  • Dapsone
  • Delavirdine
  • Deslanoside
  • Desogestrel
  • Dexamethasone
  • Diazepam
  • Dicumarol
  • Dienogest
  • Digitoxin
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Doxycycline
  • Drospirenone
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Felodipine
  • Fluconazole
  • Fludrocortisone
  • Fosphenytoin
  • Gallopamil
  • Glyburide
  • Haloperidol
  • Hydrocortisone
  • Isradipine
  • Itraconazole
  • Lacidipine
  • Lercanidipine
  • Levonorgestrel
  • Levothyroxine
  • Lorcainide
  • Medroxyprogesterone Acetate
  • Mestranol
  • Metildigoxin
  • Metoprolol
  • Mexiletine
  • Nicardipine
  • Nisoldipine
  • Nitrazepam
  • Nitrendipine
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Nortriptyline
  • Ospemifene
  • Phenprocoumon
  • Phenytoin
  • Prednisone
  • Propafenone
  • Propranolol
  • Quinidine
  • Quinine
  • Repaglinide
  • Sildenafil
  • Tacrolimus
  • Talinolol
  • Temazepam
  • Tertatolol
  • Theophylline
  • Tocainide
  • Tolbutamide
  • Triazolam
  • Valproic Acid
  • Verapamil
  • Warfarin
  • Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of rifapentine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Liver disease—There may be an increased chance of side effects affecting the liver in patients with a history of alcohol abuse or liver disease

Proper Use of rifapentine

The treatment of tuberculosis may take months or years to complete. It is very important that you comply with the full course of therapy.

Dosing

The dose of rifapentine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rifapentine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For the treatment of tuberculosis (TB):
      • Adults and children 12 years of age and older—600 milligrams (mg) twice a week with an interval of not less than three days (seventy-two hours) between doses. Rifapentine must be taken with other medicines to treat tuberculosis.
      • Infants and children up to 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of rifapentine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using rifapentine

It is very important that your doctor check your progress at regular visits.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

If rifapentine causes you to feel very tired or very weak or causes a loss of appetite, nausea, or vomiting, stop taking it and check with your doctor immediately. These may be early warning signs of more serious problems that could develop later.

Oral contraceptives (birth control pills) may not work properly if you take them while you are taking rifapentine. Unplanned pregnancies may occur. You should use a different means of birth control while you are taking rifapentine. If you have any questions about this, check with your health care professional.

Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking rifapentine. Also, the regular use of alcohol may keep rifapentine from working properly. Therefore, you should not drink alcoholic beverages while you are taking rifapentine .

Rifapentine will cause the urine, stools, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking rifapentine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. Therefore, it is best not to wear soft contact lenses while taking rifapentine. Hard contact lenses are not discolored by rifapentine. If you have any question about this, check with your doctor.

Rifapentine can lower the number of white blood cells in your blood temporarily, increasing the chance of getting infection. It can also lower the number of platelets, which are necessary for proper blood clotting. These problems may result in a greater chance of getting certain infections, slow healing, and bleeding of the gums. Be careful when using a regular toothbrush, dental floss, or a toothpick. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Before you have any medical tests, tell the doctor in charge that you are taking rifapentine.

rifapentine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Blood in urine
  • joint pain
  • lower back or side pain
  • swelling of feet or lower legs
Less common
  • Aggressive reaction
  • black, tarry stools
  • blood in stools
  • nausea
  • pinpoint red spots on skin
  • severe abdominal or stomach pain
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
  • vomiting
Rare
  • Diarrhea
  • dizziness
  • severe or continuing headaches
  • increase in blood pressure

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acne
  • constipation
  • loss of appetite

rifapentine commonly causes reddish-orange to reddish-brown discoloration of urine, stools, saliva, sputum, sweat, and tears. This side effect does not usually need medical attention.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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