raltitrexed (Intravenous route)
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Antimetabolite
Uses For raltitrexed
Raltitrexed belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum. It may also be used to treat other kinds of cancer, as determined by your doctor.
Raltitrexed blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.
Before you begin treatment with raltitrexed, you and your doctor should talk about the good raltitrexed will do as well as the risks of using it.
Raltitrexed is to be administered only by or under the immediate supervision of your doctor.
Before Using raltitrexed
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For raltitrexed, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to raltitrexed or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on raltitrexed have been done only in adult patients, and there is no specific information comparing use of raltitrexed in children with use in other age groups.
Elderly people are especially sensitive to the effects of raltitrexed. Raltitrexed may be more likely to cause side effects such as cracked lips, diarrhea, difficulty in swallowing, sores, ulcers, or white spots on the lips, tongue, or inside the mouth in elderly patients.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking raltitrexed, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using raltitrexed with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Rotavirus Vaccine, Live
Using raltitrexed with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine Type 4, Live
- Adenovirus Vaccine Type 7, Live
- Bacillus of Calmette and Guerin Vaccine, Live
- Influenza Virus Vaccine, Live
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Varicella Virus Vaccine
- Yellow Fever Vaccine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of raltitrexed. Make sure you tell your doctor if you have any other medical problems, especially:
- Chickenpox (including recent exposure) or
- Herpes zoster (shingles)—Risk of severe disease affecting other parts of the body
- Infection—Raltitrexed can decrease your body's ability to fight infection
- Kidney disease or
- Liver disease—Effects of raltitrexed may be increased because of slower removal from the body; your doctor may need to change your dose
Proper Use of raltitrexed
raltitrexed is sometimes given together with certain other medicines. If you are using a combination of medicines, it is important that you receive each one at the proper time. If you are taking some of these medicines by mouth, ask your health care professional to help you plan a way to take them at the right times.
raltitrexed usually causes nausea and vomiting that may be severe. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Ask your health care professional for ways to lessen these effects, especially if they are severe.
The dose of raltitrexed will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of raltitrexed. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For parenteral dosage form (injection):
- For colorectal cancer
- Adults—3 milligrams (mg) per square meter of body surface area given over a 15 minute period. The dose may be repeated every 3 weeks.
- Children—Use and dose must be determined by your doctor.
- For colorectal cancer
Call your doctor or pharmacist for instructions.
Precautions While Using raltitrexed
It is very important that your doctor check your progress at regular visits to make sure that raltitrexed is working properly and to check for unwanted effects.
raltitrexed may cause some people to feel unusually tired or ill. Make sure you know how you react to raltitrexed before you drive, use machines, or do anything else that could be dangerous if you are less alert.
While you are being treated with raltitrexed, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Raltitrexed may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Raltitrexed can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
- If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
- Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in urine or stools; or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
- Avoid contact sports or other situations where bruising or injury could occur.
raltitrexed Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
- Pale skin, troubled breathing, unusual bleeding or bruising, unusual tiredness or weakness
- black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands
- increase in bowel movements, loose stools, soft stools
- Dizziness, fainting, fast, slow, or irregular heartbeat, decreased urine output, dilated neck veins, extreme fatigue, irregular breathing, swelling of face, fingers, feet, or lower legs, tightness in chest, weight gain, wheezing
- Stomach or abdomen pain
- loss of appetite, weight loss
- nausea and vomiting
- lack or loss of strength
- general feeling of discomfort or illness, headache, joint pain, muscle aches and pains, runny nose, shivering, sweating, trouble sleeping
- Bloating or swelling of face, arms, hands, lower legs, or feet, rapid weight gain, tingling of hands or feet
- Hair loss, thinning of hair
- Change in taste, bad unusual or unpleasant (after)taste
After you stop using raltitrexed, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
- Black, tarry stools, blood in urine or stools, cough or hoarseness, fever or chills, lower back or side pain, painful or difficult urination, pinpoint red spots on skin, unusual bleeding or bruising
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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