pyrazinamide (Oral route)

pir-a-ZIN-a-mide

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antitubercular

Uses For pyrazinamide

Pyrazinamide belongs to the family of medicines called anti-infectives. It is used, along with other medicines, to treat tuberculosis (TB).

To help clear up your tuberculosis (TB) infection completely, you must keep taking pyrazinamide for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

Pyrazinamide is available only with your doctor's prescription.

Before Using pyrazinamide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pyrazinamide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pyrazinamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Pyrazinamide has been used in children and, in effective doses, has not been reported to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing pyrazinamide in the elderly with use in other age groups, pyrazinamide is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking pyrazinamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using pyrazinamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Ethionamide
  • Rifampin
  • Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pyrazinamide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Gout (history of)—Pyrazinamide may worsen or cause a gout attack in patients with a history of gout
  • Liver disease (severe)—Patients with severe liver disease who take pyrazinamide may have an increase in side effects

Proper Use of pyrazinamide

To help clear up your TB completely, it is important that you keep taking pyrazinamide for the full time of treatment, even if you begin to feel better after a few weeks. It is important that you do not miss any doses.

Dosing

The dose of pyrazinamide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pyrazinamide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For tuberculosis (TB):
      • Adults and children—Dose is based on body weight. The usual dose is 15 to 30 milligrams (mg) of pyrazinamide per kilogram (kg) (6.8 to 13.6 mg per pound) of body weight once a day; or 50 to 70 mg per kg (22.7 to 31.8 mg per pound) two times a week or three times a week, depending on the schedule your doctor chooses for you. pyrazinamide must be taken along with other medicines used to treat TB.

Missed Dose

If you miss a dose of pyrazinamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using pyrazinamide

It is very important that your doctor check your progress at regular visits.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

For diabetic patients:

  • pyrazinamide may cause false test results with urine ketone tests. Check with your doctor before changing your diet or the dosage of your diabetes medicine.

pyrazinamide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Pain in large and small joints
Rare
  • Loss of appetite
  • pain and swelling of joints, especially big toe, ankle, and knee
  • tense, hot skin over affected joints
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
  • Itching
  • skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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