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mupirocin (Topical route)

Pronunciation

mue-PIR-oh-sin

Commonly used brand name(s)

In the U.S.

  • Bactroban
  • Centany
  • Centany AT

Available Dosage Forms:

  • Ointment
  • Cream

Therapeutic Class: Antibacterial

Uses For mupirocin

Mupirocin topical cream is used to treat secondarily infected traumatic skin lesions due to specific bacteria. Mupirocin topical ointment is used to treat impetigo. mupirocin works by killing bacteria or preventing their growth.

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mupirocin is available only with your doctor's prescription.

Before Using mupirocin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mupirocin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to mupirocin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of mupirocin topical in children. However, safety and effectiveness of mupirocin cream have not been established in children younger than 3 months of age, and mupirocin ointment in children younger than 2 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mupirocin topical cream in the elderly.

No information is available on the relationship of age to the effects of mupirocin topical ointment in the geriatric population. Safety and efficacy have not been established.

Pregnancy

Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of mupirocin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea—Use with caution. May make this condition worse.

Proper Use of mupirocin

It is very important that you use mupirocin only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

mupirocin should only be used on the skin. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

To help clear up your skin infection completely, keep using mupirocin for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.

To use:

  • Wash your hands with soap and water before and after using mupirocin.
  • Apply a thin layer to the affected area of the skin. Rub it in gently.
  • After applying mupirocin, the treated area may be covered with a gauze dressing if desired.

Dosing

The dose of mupirocin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of mupirocin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (cream):
    • For treatment of secondarily infected traumatic skin lesions:
      • Adults and children 3 months of age and older—Apply three times a day for 10 days.
      • Children younger than 3 months of age—Use and dose must be determined by your doctor.
  • For topical dosage form (ointment):
    • For treatment of impetigo:
      • Adults and children 2 months of age and older—Apply three times a day.
      • Children younger than 2 months of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of mupirocin, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using mupirocin

If your skin infection does not improve within 3 to 5 days, or if it becomes worse, check with your doctor.

mupirocin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using mupirocin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Check with your doctor right away if you have a severe itching, skin rash, burning, stinging, redness, swelling, or irritation on the skin.

mupirocin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Burning, stinging, or pain on the application site
Rare
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • canker sores
  • cracked, dry, scaly skin
  • pain, swelling, tenderness, warmth on the skin
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
Incidence not known
  • Abdominal or stomach tenderness
  • cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • severe abdominal or stomach cramps and pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Headache
  • nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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