meprobamate (Oral route)

Pronunciation

me-proe-BAM-ate

Commonly used brand name(s)

In the U.S.

  • Mb-Tab
  • Miltown
  • Trancot

Available Dosage Forms:

  • Tablet
  • Capsule, Extended Release

Therapeutic Class: Antianxiety

Chemical Class: Carbamate

Uses For meprobamate

Meprobamate is used to relieve nervousness or tension. meprobamate should not be used for nervousness or tension caused by the stress of everyday life.

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Meprobamate is available only with your doctor's prescription.

Before Using meprobamate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For meprobamate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to meprobamate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on meprobamate have been done only in adult patients, and there is no specific information comparing use of meprobamate in children with use in other age groups.

Geriatric

Elderly people may be especially sensitive to the effects of meprobamate. This may increase the chance of side effects during treatment.

Pregnancy

Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking meprobamate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using meprobamate with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adinazolam
  • Alfentanil
  • Alprazolam
  • Amobarbital
  • Anileridine
  • Aprobarbital
  • Bromazepam
  • Brotizolam
  • Buprenorphine
  • Butabarbital
  • Butalbital
  • Carbinoxamine
  • Carisoprodol
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorzoxazone
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Codeine
  • Dantrolene
  • Diazepam
  • Eslicarbazepine Acetate
  • Estazolam
  • Ethchlorvynol
  • Fentanyl
  • Flunitrazepam
  • Flurazepam
  • Fospropofol
  • Halazepam
  • Hydrocodone
  • Hydromorphone
  • Ketazolam
  • Levorphanol
  • Lorazepam
  • Lormetazepam
  • Meclizine
  • Medazepam
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methocarbamol
  • Methohexital
  • Midazolam
  • Nitrazepam
  • Nordazepam
  • Oxazepam
  • Oxycodone
  • Pentobarbital
  • Phenobarbital
  • Prazepam
  • Primidone
  • Propoxyphene
  • Quazepam
  • Remifentanil
  • Secobarbital
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thiopental
  • Triazolam
  • Zolpidem

Using meprobamate with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Perampanel

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of meprobamate. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Drug abuse or dependence (or history of)—Dependence on meprobamate may develop
  • Epilepsy—The risk of seizures may be increased
  • Kidney disease or
  • Liver disease—Higher blood levels of meprobamate may occur, increasing the chance of side effects
  • Porphyria—Meprobamate may make the condition worse

Proper Use of meprobamate

Take meprobamate only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming.

Dosing

The dose of meprobamate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of meprobamate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For regular (short-acting) tablets:
    • Adults and children 12 years of age and older: 400 milligrams three or four times a day, or 600 milligrams two times a day.
    • Children 6 to 12 years of age: 100 to 200 milligrams two or three times a day.
    • Children up to 6 years of age: Dose must be determined by the doctor.
  • For long-acting dosage forms (extended-release tablets):
    • Adults and children 12 years of age or older: 400 to 800 milligrams two times a day, in the morning and at bedtime.
    • Children 6 to 12 years of age: 200 milligrams two times a day, in the morning and at bedtime.
    • Children up to 6 years of age: Dose must be determined by the doctor.

Missed Dose

If you miss a dose of meprobamate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using meprobamate

If you will be taking meprobamate regularly for a long time:

  • Your doctor should check your progress at regular visits.
  • Check with your doctor at least every 4 months to make sure you need to continue taking meprobamate.

If you will be taking meprobamate in large doses or for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

meprobamate will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking meprobamate.

Before you have any medical tests, tell the medical doctor in charge that you are taking meprobamate. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by meprobamate.

If you think you or someone else may have taken an overdose of meprobamate, get emergency help at once. Taking an overdose of meprobamate or taking alcohol or other CNS depressants with meprobamate may lead to unconsciousness and possibly death. Some signs of an overdose are severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; slurred speech; staggering; and slow heartbeat.

meprobamate may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to meprobamate before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

Meprobamate may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

meprobamate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Skin rash, hives, or itching
Rare
  • Confusion
  • fast, pounding, or irregular heartbeat
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual excitement
  • wheezing, shortness of breath, or troubled breathing
Symptoms of overdose
  • Confusion (severe)
  • dizziness or lightheadedness (continuing)
  • drowsiness (severe)
  • shortness of breath or slow or troubled breathing
  • slow heartbeat
  • slurred speech
  • staggering
  • weakness (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Clumsiness or unsteadiness
  • drowsiness
Less common
  • Blurred vision or change in near or distant vision
  • diarrhea
  • dizziness or lightheadedness
  • false sense of well-being
  • headache
  • nausea or vomiting
  • unusual tiredness or weakness

After you stop using meprobamate, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Clumsiness or unsteadiness
  • confusion
  • convulsions (seizures)
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increased dreaming
  • muscle twitching
  • nausea or vomiting
  • nervousness or restlessness
  • nightmares
  • trembling
  • trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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