lincomycin (Oral route, Injection route)

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Injection route(Solution)

Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including lincomycin, and may range in severity from mild to life-threatening. Therefore, lincomycin therapy should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C difficile may need to be discontinued. Appropriate supportive therapy, such as fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation should be instituted as clinically indicated .

Commonly used brand name(s)

In the U.S.

  • Lincocin

Available Dosage Forms:

  • Capsule
  • Solution

Therapeutic Class: Antibiotic

Chemical Class: Lincosamide

Uses For lincomycin

Lincomycin belongs to the family of medicines called antibiotics. These medicines are used to treat infections. They will not work for colds, flu, or other virus infections.

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Lincomycin is available only with your doctor's prescription.

Before Using lincomycin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lincomycin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lincomycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Lincomycin has been used in children 1 month of age or older and has not been reported to cause different side effects or problems than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of lincomycin in the elderly with use in other age groups.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of lincomycin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease (severe) or
  • Liver disease (severe)—Severe kidney or liver disease may increase blood levels of lincomycin, increasing the chance of side effects
  • Stomach or intestinal disease, history of (especially colitis, including colitis caused by antibiotics, or enteritis)—Patients with a history of stomach or intestinal disease may have an increased chance of side effects

Proper Use of lincomycin

Lincomycin is best taken with a full glass (8 ounces) of water on an empty stomach (either 1 hour before or 2 hours after meals), unless otherwise directed by your doctor.

To help clear up your infection completely, keep taking lincomycin for the full time of treatment, even if you begin to feel better after a few days. If you have a ``strep'' infection, you should keep taking lincomycin for at least 10 days. This is especially important in ``strep'' infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking lincomycin too soon, your symptoms may return.

lincomycin works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. For example, if you are to take 4 doses a day, doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Dosing

The dose of lincomycin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lincomycin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For infections caused by bacteria:
    • For oral dosage form (capsules):
      • Adults and teenagers—500 milligrams (mg) every six to eight hours.
      • Infants up to 1 month of age—Use and dose must be determined by your doctor.
      • Children 1 month of age and older—Dose is based on body weight. The usual dose is 7.5 to 15 mg per kilogram (kg) (3.4 to 6.8 mg per pound) of body weight every six hours; or 10 to 20 mg per kg (4.5 to 9.1 mg per pound) of body weight every eight hours.
    • For injection dosage form:
      • Adults and teenagers—600 mg to 1 gram injected into a vein over at least one hour, every eight to twelve hours; or 600 mg injected into a muscle every twelve to twenty-four hours.
      • Infants up to 1 month of age—Use and dose must be determined by your doctor.
      • Children 1 month of age and older—Dose is based on body weight. The usual dose is 10 mg per kg (4.5 mg per pound) of body weight injected into a muscle every twelve to twenty-four hours; or 3.3 to 6.7 mg per kg (1.5 to 3 mg per pound) of body weight injected into a vein every eight hours; or 5 to 10 mg per kg (2.3 to 4.5 mg per pound) of body weight injected into a vein every twelve hours.

Missed Dose

If you miss a dose of lincomycin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using lincomycin

It is important that your doctor check your progress at regular visits.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

In some patients, lincomycin may cause diarrhea.

  • Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor . Diarrhea medicines may make your diarrhea worse or make it last longer.
  • For mild diarrhea, diarrhea medicine containing attapulgite (e.g., Kaopectate tablets, Diasorb) may be taken. However, kaolin or attapulgite may keep lincomycin from being absorbed into the body. Therefore, these diarrhea medicines should be taken at least 2 hours before or 3 to 4 hours after you take lincomycin by mouth. Other kinds of diarrhea medicine should not be taken. They may make your diarrhea worse or make it last longer.
  • If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.

Before having surgery (including dental surgery) with a general anesthetic, tell the medical doctor or dentist in charge that you are taking lincomycin.

lincomycin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Abdominal or stomach cramps and pain (severe)
  • abdominal tenderness
  • diarrhea (watery and severe), which may also be bloody
  • fever
Less common
  • Skin rash, redness, and itching
  • sore throat and fever
  • unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you stop taking lincomycin.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea (mild)
  • nausea and vomiting
  • stomach pain
Less common
  • Itching of rectal or genital (sex organ) areas

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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