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isoxsuprine (Oral route, Injection route)

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Commonly used brand name(s)

In the U.S.

  • Vasodilan

Available Dosage Forms:

  • Tablet

Therapeutic Class: Peripheral Vasodilator

Uses For isoxsuprine

Isoxsuprine belongs to the group of medicines called vasodilators. Vasodilators increase the size of blood vessels. Isoxsuprine is used to treat problems resulting from poor blood circulation.

It may also be used for other conditions as determined by your doctor.

Isoxsuprine is available only with your doctor's prescription.

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Although this use is not included in U.S. product labeling, isoxsuprine is used in certain women to stop premature labor.

In addition to the above information, the following information applies when isoxsuprine is used to stop premature labor:

  • Before you begin treatment with isoxsuprine, tell your doctor if you have any of the following medical problems:
    • Asthma
    • Type 2 diabetes mellitus
    • Heart disease
    • High blood pressure
    • Overactive thyroid
  • Check with your doctor immediately:
    • if your contractions begin again or your water breaks.
    • if you notice chest pain or shortness of breath while taking isoxsuprine.

Before Using isoxsuprine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For isoxsuprine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to isoxsuprine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of isoxsuprine in the elderly with use in other age groups. However, isoxsuprine may reduce tolerance to cold temperatures in elderly patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of isoxsuprine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain) or
  • Bleeding problems or
  • Glaucoma or
  • Hardening of the arteries or
  • Heart attack (recent) or
  • Stroke (recent)—The chance of side effects may be increased

Proper Use of isoxsuprine

If isoxsuprine upsets your stomach, it may be taken with meals, milk, or antacids.

Dosing

The dose of isoxsuprine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of isoxsuprine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For poor blood circulation:
      • Adults—10 to 20 milligrams (mg) three or four times a day.

Missed Dose

If you miss a dose of isoxsuprine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using isoxsuprine

It may take some time for isoxsuprine to work. If you feel that the medicine is not working, do not stop taking it on your own. Instead, check with your doctor.

The helpful effects of isoxsuprine may be decreased if you smoke. If you have any questions about this, check with your doctor.

Dizziness may occur, especially when you get up from a lying or sitting position or climb stairs. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

isoxsuprine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare
  • Chest pain
  • dizziness or faintness (more common for injection)
  • fast heartbeat (more common for injection)
  • shortness of breath
  • skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Nausea or vomiting (more common for injection)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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