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droperidol (Injection route)

Pronunciation

droe-PER-i-dol

Injection route(Solution)

Cases of QT prolongation and/or torsade de pointes, some fatal, have been reported in patients receiving droperidol at doses at or below recommended doses. All patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. Do not administer droperidol if there is a prolonged QT interval. Droperidol is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome. Administer droperidol with extreme caution to patients who may be at risk for development of prolonged QT syndrome, are over 65 years old, abuse alcohol, or when used concomitantly with benzodiazepines, volatile anesthetics, and IV opiates. ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias .

Commonly used brand name(s)

In the U.S.

  • Inapsine

Available Dosage Forms:

  • Injectable
  • Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Dopamine Antagonist

Chemical Class: Butyrophenone

Uses For droperidol

Droperidol is used to reduce the amount of nausea and vomiting you may have after surgery or other procedures.

droperidol is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, droperidol is used

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  • In certain patients with severe agitation and combativeness
  • To produce sleepiness or drowsiness before surgery or certain procedures

For patients receiving droperidol for severe agitation and combativeness, the dose administered will depend on the degree of agitation and the size of the patient.

Before Using droperidol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For droperidol, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to droperidol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Droperidol has not been studied in children up to 2 years of age. There is no specific information comparing the use of droperidol in children with use in other age groups. However, based on experience with similar drugs, children may be more likely than older patients to experience side effects after receiving droperidol, such as muscle spasms in the tongue, face, neck, and back, and inability to move the eyes.

Geriatric

Older patients may be more likely than younger adult patients to experience dizziness and excessive sleepiness from droperidol. Older patients may also have problems with unusual heartbeats from droperidol

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving droperidol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using droperidol with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acetophenazine
  • Amifampridine
  • Bepridil
  • Bromperidol
  • Cisapride
  • Clozapine
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Molindone
  • Perphenazine
  • Pimozide
  • Pipamperone
  • Piperaquine
  • Remoxipride
  • Sparfloxacin
  • Thioridazine
  • Tiapride
  • Triflupromazine
  • Ziprasidone

Using droperidol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Acetazolamide
  • Ajmaline
  • Alfuzosin
  • Amiloride
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Apomorphine
  • Aprindine
  • Aranidipine
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Azosemide
  • Bedaquiline
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Bretylium
  • Brofaromine
  • Bumetanide
  • Canrenoate
  • Castor Oil
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Chlorthalidone
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clopamide
  • Clorgyline
  • Crizotinib
  • Cyclobenzaprine
  • Cyclothiazide
  • Dasatinib
  • Desipramine
  • Dibenzepin
  • Diltiazem
  • Disopyramide
  • Docusate
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Ebastine
  • Encainide
  • Enflurane
  • Erythromycin
  • Ethacrynic Acid
  • Etozolin
  • Felodipine
  • Fendiline
  • Fenquizone
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Flunarizine
  • Fluoxetine
  • Fluspirilene
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Furazolidone
  • Furosemide
  • Gallopamil
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indapamide
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Lacidipine
  • Lactulose
  • Lapatinib
  • Lazabemide
  • Levofloxacin
  • Lidoflazine
  • Linezolid
  • Lithium
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Mannitol
  • Mefloquine
  • Methadone
  • Metolazone
  • Mianserin
  • Mibefradil
  • Mifepristone
  • Moclobemide
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nefazodone
  • Nialamide
  • Nicardipine
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Pargyline
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Phenelzine
  • Piretanide
  • Pirmenol
  • Polythiazide
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinethazone
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Risperidone
  • Ritanserin
  • Salmeterol
  • Saquinavir
  • Selegiline
  • Sematilide
  • Sertindole
  • Sertraline
  • Sibutramine
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sorbitol
  • Sotalol
  • Spiramycin
  • Spironolactone
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Ticrynafen
  • Tizanidine
  • Toloxatone
  • Toremifene
  • Torsemide
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trichlormethiazide
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Urea
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Xipamide
  • Zimeldine
  • Zolmitriptan
  • Zotepine

Using droperidol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Levodopa

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of droperidol. Make sure you tell your doctor if you have any other medical problems, especially:

  • Age over 65 or
  • Alcoholism or
  • Congestive heart failure or
  • Enlargement of the heart or
  • Hypokalemia (too little potassium in the blood) or
  • Hypomagnesemia (too little magnesium in the blood) or
  • Irregular heartbeat
  • Slow heartbeat—Droperidol may increase the risk of irregular heartbeats
  • Epilepsy—The risk of seizures may be increased
  • Heart disease or
  • Mental depression or
  • Parkinsonism—Droperidol may worsen these conditions
  • Hypovolemia—The risk of dizziness may be increased
  • Liver disease—The risk of side effects may be increased
  • Pheochromocytoma—High blood pressure and rapid heart rate may occur

Proper Use of droperidol

Dosing

The dose of droperidol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of droperidol. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • Your age;
  • Your general physical condition;
  • The reason you are receiving droperidol; and
  • Other medicines you are taking or will receive before or after droperidol is given.

Precautions While Using droperidol

For patients going home within a few hours after surgery:

  • Droperidol and other medicines that may be given during surgery may cause some people to feel drowsy, tired, or weak for up to a few days afterwards. Therefore, for at least 24 hours (or longer if necessary) after receiving droperidol, do not drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
  • Unless otherwise directed by your medical doctor, do not drink alcoholic beverages or take other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness) for about 24 hours after you have received droperidol. To do so may add to the effects of droperidol. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; and muscle relaxants.

droperidol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Anxiety
  • high blood pressure
  • restlessness
Rare
  • Fainting
  • fever
  • fixed upward position of the eyeballs
  • irregular or slow heart rate
  • spasm of the muscles of the tongue, face, neck, and back
  • sudden death

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Symptoms of overdose
  • Dizziness
  • fixed upward position of the eyeballs
  • restlessness
  • slowed breathing
  • spasm of the muscles of the tongue, face, neck, and back

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Drowsiness
  • lightheadedness
  • rapid heart rate

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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