domperidone (Oral route)

dome-PER-i-done

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antiemetic

Pharmacologic Class: Dopamine Antagonist

Uses For domperidone

Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Domperidone is to be given only by or under the immediate supervision of your doctor.

Before Using domperidone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For domperidone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to domperidone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Children—Studies on domperidone have been done only in adult patients, and there is no specific information comparing use of domperidone in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of domperidone in the elderly with use in other age groups.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving domperidone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using domperidone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Cisapride
  • Dronedarone
  • Fluconazole
  • Ketoconazole
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Sparfloxacin
  • Thioridazine
  • Ziprasidone

Using domperidone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfuzosin
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Amprenavir
  • Apomorphine
  • Aprepitant
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Atorvastatin
  • Azithromycin
  • Bicalutamide
  • Boceprevir
  • Chloroquine
  • Chlorpromazine
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Dasatinib
  • Delavirdine
  • Desipramine
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Droperidol
  • Erythromycin
  • Escitalopram
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Fluvoxamine
  • Fosamprenavir
  • Gemifloxacin
  • Ginkgo Biloba
  • Goldenseal
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Ibutilide
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Isoniazid
  • Itraconazole
  • Ivabradine
  • Lapatinib
  • Levofloxacin
  • Lithium
  • Lopinavir
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Mifepristone
  • Moxifloxacin
  • Nefazodone
  • Nelfinavir
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranitidine
  • Ranolazine
  • Ritonavir
  • Salmeterol
  • Saquinavir
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Ticagrelor
  • Tizanidine
  • Toremifene
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Verapamil
  • Vilanterol
  • Vinflunine
  • Voriconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using domperidone with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use domperidone, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of domperidone. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding from the stomach or other problems involving the bowels
  • Pituitary (brain) tumor
  • Liver disease
  • Medicine sensitivity to domperidone

Proper Use of domperidone

Dosing

The dose of domperidone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of domperidone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • Treatment of gastrointestinal motility disorders:
      • Adults—10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily.
    • Nausea and vomiting:
      • Adults—20 milligrams (mg) three to four times daily.

Missed Dose

If you miss a dose of domperidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using domperidone

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

domperidone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

  • Difficulty in speaking
  • disorientation
  • dizziness
  • fainting
  • irregular heartbeat
  • light-headedness
  • loss of balance or muscle control

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Loss of balance or muscle control
  • swelling of the mouth
Rare
  • Fast, irregular, pounding, or racing heartbeat or pulse
  • swelling of face, hands, lower legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Breast milk flowing from the nipple
  • dry mouth
  • swelling of the breast in the male
  • headache
  • hives
  • hot flashes
  • itching of skin
  • itching, redness, pain, or swelling of eye
  • menstrual irregularities
  • pain in the breast
Rare
  • Change in need to urinate
  • change in appetite
  • constipation
  • diarrhea
  • burning, difficult, or painful urination
  • difficulty in speaking
  • dizziness
  • drowsiness
  • heartburn
  • irritability
  • lack or loss of strength
  • leg cramps
  • mental dullness
  • nervousness
  • palpitations
  • sluggishness
  • stomach cramps
  • thirst
  • tiredness
  • weakness

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