diethylcarbamazine (Oral route)

dye-eth-il-kar-BAM-a-zeen

Available Dosage Forms:

  • Tablet

Uses For diethylcarbamazine

Diethylcarbamazine is used in the treatment of certain worm infections. diethylcarbamazine works by killing the worms. It is used to treat:

  • Bancroft's filariasis;
  • Eosinophilic lung (tropical pulmonary eosinophilia; tropical eosinophilia);
  • Loiasis; and
  • River blindness (onchocerciasis).

It will not work for other kinds of worm infections (for example, pinworms or tapeworms).

Diethylcarbamazine is available only with your doctor's prescription, and only from the manufacturer.

Before Using diethylcarbamazine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For diethylcarbamazine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to diethylcarbamazine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of diethylcarbamazine in children with use in other age groups, diethylcarbamazine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of diethylcarbamazine in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of diethylcarbamazine

Diethylcarbamazine should be taken immediately after meals.

To help clear up your infection completely, keep taking diethylcarbamazine for the full time of treatment, even if your symptoms begin to clear up after a few days. In some patients, a second course of diethylcarbamazine may be required to clear up the infection completely. If you stop taking diethylcarbamazine too soon, your infection may return. Do not miss any doses.

Dosing

The dose of diethylcarbamazine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of diethylcarbamazine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For Bancroft's filariasis, loiasis, and river blindness:
      • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 3 milligrams (mg) per kilogram (kg) (0.9 to 1.3 mg per pound) of body weight three times a day.
      • Children—Use and dose must be determined by your doctor.
    • For eosinophilic lung:
      • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 6 mg per kg (2.7 mg per pound) of body weight a day. This is taken for four to seven days.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of diethylcarbamazine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using diethylcarbamazine

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

For patients taking diethylcarbamazine for river blindness:

  • It is important that your doctor check your progress at regular visits. This is to help make sure that the infection is cleared up completely. Also, your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
  • Diethylcarbamazine may cause loss of vision, night blindness, or tunnel vision with prolonged use. diethylcarbamazine may also cause some people to become dizzy. Make sure you know how you react to diethylcarbamazine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. If these reactions are especially bothersome, check with your doctor.
  • Doctors may also prescribe a corticosteroid (a cortisone-like medicine) for certain patients with river blindness, especially those with severe symptoms. This is to help reduce the inflammation caused by the death of the worms. If your doctor prescribes these two medicines together, it is important to take the corticosteroid along with diethylcarbamazine. Take them exactly as directed by your doctor. Do not miss any doses.

diethylcarbamazine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Itching and swelling of the face, especially the eyes
Less common
  • Fever
  • painful and tender glands in the neck, armpits, or groin
  • skin rash

Check with your doctor as soon as possible if any of the following side effects occur:

  • Loss of vision
  • night blindness
  • tunnel vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
  • joint pain
  • unusual tiredness or weakness
Less common
  • Dizziness
  • nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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