colestipol (Oral route)Pronunciation
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Suspension
Therapeutic Class: Antihyperlipidemic
Pharmacologic Class: Bile Acid Sequestrant
Uses For colestipol
Colestipol is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels.
Colestipol works by attaching to certain substances in the intestine. Since colestipol is not absorbed into the body, these substances also pass out of the body without being absorbed.
Colestipol may also be used for other conditions as determined by your doctor.
Colestipol is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, colestipol is used in certain patients with the following medical conditions:
- Diarrhea caused by bile acids
- Digitalis glycoside overdose
- Excess oxalate in the urine
- Itching (pruritus) associated with partial biliary obstruction
Before Using colestipol
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For colestipol, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to colestipol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
There is no specific information comparing use of colestipol in children with use in other age groups. However, use is not recommended in children under 2 years of age since cholesterol is needed for normal development.
Side effects may be more likely to occur in patients over 60 years of age, who are usually more sensitive to the effects of colestipol.
Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking colestipol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using colestipol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Mycophenolate Mofetil
- Mycophenolic Acid
Using colestipol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of colestipol. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Constipation or
- Gallstones or
- Heart or blood vessel disease or
- Hemorrhoids or
- Stomach ulcer or other stomach problems or
- Underactive thyroid—Colestipol may make these conditions worse
- Kidney disease—There is an increased risk of developing electrolyte problems
- Liver disease—Cholesterol levels may be raised
Proper Use of colestipol
Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.
Also, colestipol is less effective if you are greatly overweight. It may be very important for you to go on a reducing diet. However, check with your doctor before going on any diet.
Make certain your health care professional knows if you are on a low-sodium, low-sugar, or any other special diet.
Take colestipol exactly as directed by your doctor . Try not to miss any doses and do not take more medicine than your doctor ordered.
Follow carefully the special diet your doctor gave you. This is the most important part of controlling your condition and is necessary if the medicine is to work properly.
colestipol should never be taken in its dry form, since it could cause you to choke. Instead, always mix as follows:
- Add colestipol to 3 ounces or more of water, milk, flavored drink, or your favorite juice or carbonated drink. If you use a carbonated drink, slowly mix in the powder in a large glass to prevent too much foaming. Stir until it is completely mixed (it will not dissolve) before drinking. After drinking all the liquid containing the medicine, rinse the glass with a little more liquid and drink that also, to make sure you get all the medicine.
- You may also mix colestipol with milk in hot or regular breakfast cereals, or in thin soups such as tomato or chicken noodle soup. Or you may add it to some pulpy fruits such as crushed pineapple, pears, peaches, or fruit cocktail.
The dose of colestipol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of colestipol. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (powder for oral suspension):
- For high cholesterol:
- Adults—15 to 30 grams a day. This is divided into two to four doses and taken before meals.
- Children—Use and dose must be determined by your doctor.
- For high cholesterol:
If you miss a dose of colestipol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using colestipol
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly to lower your cholesterol levels and to decide if you should continue to take it.
Do not stop taking colestipol without first checking with your doctor. When you stop taking colestipol, your blood cholesterol levels may increase again. Your doctor may want you to follow a special diet to help prevent this from happening.
Do not take any other medicine unless prescribed by your doctor since colestipol may interfere with other medicines.
colestipol Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Rare
- Black, tarry stools
- stomach pain (severe) with nausea and vomiting
Check with your doctor as soon as possible if any of the following side effects occur:More common
- Loss of weight (sudden)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- nausea or vomiting
- stomach pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: colestipol side effects (in more detail)
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