clioquinol and hydrocortisone (Topical route)

klye-oh-KWIN-ol, hye-droe-KOR-ti-sone

Commonly used brand name(s)

In the U.S.

  • Dermasorb AF Complete Kit

In Canada

  • Vioform Hydrocortisone
  • Vioform Hydrocortisone Mild

Available Dosage Forms:

  • Cream
  • Ointment

Therapeutic Class: Anti-Infective/Anti-Inflammatory Combination

Pharmacologic Class: Adrenal Glucocorticoid

Uses For clioquinol and hydrocortisone

Clioquinol and hydrocortisone is a combined anti-infective and cortisone-like medicine. Clioquinol and hydrocortisone topical preparations are used to treat infections of the skin and to help provide relief from the redness, itching, and discomfort of many skin problems.

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Clioquinol and hydrocortisone combination is available only with your doctor's prescription.

Before Using clioquinol and hydrocortisone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For clioquinol and hydrocortisone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to clioquinol and hydrocortisone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Clioquinol and hydrocortisone combination is not recommended in children up to 2 years of age. Although there is no specific information comparing use of clioquinol and hydrocortisone combination in children over 2 years of age with use in other age groups, clioquinol and hydrocortisone is not expected to cause different side effects or problems in these children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of clioquinol and hydrocortisone combination in the elderly with use in other age groups, clioquinol and hydrocortisone is not expected to cause different side effects or problems in older people than it does in younger adults.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking clioquinol and hydrocortisone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using clioquinol and hydrocortisone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using clioquinol and hydrocortisone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aldesleukin
  • Bupropion
  • Itraconazole
  • Piperaquine
  • Pixantrone
  • Topotecan

Using clioquinol and hydrocortisone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alatrofloxacin
  • Alcuronium
  • Atracurium
  • Balofloxacin
  • Cinoxacin
  • Ciprofloxacin
  • Clinafloxacin
  • Colestipol
  • Enoxacin
  • Fleroxacin
  • Flumequine
  • Gallamine
  • Gemifloxacin
  • Grepafloxacin
  • Hexafluorenium
  • Levofloxacin
  • Licorice
  • Lomefloxacin
  • Metocurine
  • Moxifloxacin
  • Norfloxacin
  • Ofloxacin
  • Pefloxacin
  • Primidone
  • Prulifloxacin
  • Rifapentine
  • Rosoxacin
  • Rufloxacin
  • Saiboku-To
  • Sparfloxacin
  • Temafloxacin
  • Tosufloxacin
  • Trovafloxacin Mesylate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of clioquinol and hydrocortisone. Make sure you tell your doctor if you have any other medical problems, especially:

  • Skin infection (other)—Use of clioquinol and hydrocortisone topical preparations may make the condition worse

Proper Use of clioquinol and hydrocortisone

Before applying clioquinol and hydrocortisone, wash the affected area with soap and water, and dry thoroughly.

Do not use clioquinol and hydrocortisone in or around the eyes or on infants and children up to 2 years of age.

To use the cream form of clioquinol and hydrocortisone:

  • Apply a thin layer of cream to the affected area and rub in gently until cream disappears.

To use the lotion form of clioquinol and hydrocortisone:

  • Gently squeeze bottle and apply a few drops of lotion to the affected area. Rub in gently until lotion disappears.

To use the ointment form of clioquinol and hydrocortisone:

  • Apply a thin layer of ointment to the affected area and rub in gently.

Do not bandage or otherwise wrap the area of the skin being treated unless directed to do so by your doctor.

Check with your doctor before using clioquinol and hydrocortisone on any other skin problems. It should not be used on certain kinds of bacterial, virus, or fungus skin infections.

To help clear up your infection completely, keep using clioquinol and hydrocortisone for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses. However, do not use clioquinol and hydrocortisone more often or for a longer time than your doctor ordered. To do so may increase the chance of absorption through the skin and the chance of side effects. In addition, too much use, especially on thin skin areas (for example, face, armpits, groin), may result in thinning of the skin and stretch marks.

Dosing

The dose of clioquinol and hydrocortisone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of clioquinol and hydrocortisone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage forms (cream, lotion, or ointment):
    • For bacterial and fungus infections:
      • Adults, teenagers, and children 2 years of age and over—Apply to the affected area(s) of the skin three or four times a day.
      • Children up to 2 years of age—Use is not recommended.

Missed Dose

If you miss a dose of clioquinol and hydrocortisone, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using clioquinol and hydrocortisone

If your skin problem does not improve within 1 to 2 weeks, or if it becomes worse, check with your doctor.

clioquinol and hydrocortisone may be absorbed through the skin, and too much use can affect growth. Children who must use clioquinol and hydrocortisone should be followed closely by their doctor.

clioquinol and hydrocortisone may stain clothing, skin, hair, and nails yellow. Avoid getting clioquinol and hydrocortisone on your clothing. Bleaching may not remove the stain.

clioquinol and hydrocortisone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Blistering, burning, itching, peeling, skin rash, redness, swelling, or other sign of irritation not present before use of clioquinol and hydrocortisone
With prolonged use
  • Thinning of skin with easy bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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