clindamycin and tretinoin (Topical application route)

klin-da-MYE-sin FOS-fate, TRET-i-noin

Commonly used brand name(s)

In the U.S.

  • Veltin
  • Ziana

Available Dosage Forms:

  • Gel/Jelly

Therapeutic Class: Antiacne

Chemical Class: Clindamycin

Uses For clindamycin and tretinoin

Clindamycin and tretinoin topical is used to treat acne. It works by killing the bacteria that cause acne and by keeping the skin pores (tiny openings on the skin's surface) clear.

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clindamycin and tretinoin is available only with your doctor's prescription.

Before Using clindamycin and tretinoin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For clindamycin and tretinoin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to clindamycin and tretinoin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of clindamycin and tretinoin topical in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of clindamycin and tretinoin topical have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking clindamycin and tretinoin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using clindamycin and tretinoin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Erythromycin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of clindamycin and tretinoin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis caused by antibiotics, history of or
  • Crohn's disease or
  • Ulcerative colitis—Should not be used in patients with these conditions.

Proper Use of clindamycin and tretinoin

It is very important that you use clindamycin and tretinoin only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause your skin to become too dry or irritated. You may need to use clindamycin and tretinoin for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster.

clindamycin and tretinoin is for use on the skin only. Do not get it in your eyes, mouth, nose, on the corners of your nose, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away.

clindamycin and tretinoin comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

To use:

  • Wash your hands with soap and water before and after using clindamycin and tretinoin.
  • Before applying clindamycin and tretinoin, wash your face with warm water and a mild soap, rinse well, and pat dry.
  • Apply just enough medicine to lightly cover the affected areas, and rub it in gently but well. A pea-sized amount is enough to cover the whole face.
  • You should not wash your face too often, 2 or 3 times a day is enough. Washing your face too often may dry your skin and make the acne worse.

Dosing

The dose of clindamycin and tretinoin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of clindamycin and tretinoin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For acne:
      • Adults and teenagers—Apply to the affected area(s) of the skin once a day, at bedtime.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of clindamycin and tretinoin, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using clindamycin and tretinoin

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Stop using clindamycin and tretinoin and call your doctor right away if you start having severe, watery diarrhea or bloody diarrhea. This could be a sign of a serious side effect. Do not take any medicine for diarrhea without checking first with your doctor. Some medicines may make your diarrhea worse or make it last longer.

clindamycin and tretinoin may make your skin more sensitive to sunlight, wind, and cold weather. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. You may need to wear protective clothing, such as a hat.

Skin reactions can occur when you use clindamycin and tretinoin, such as dryness, redness, peeling, burning, or stinging. Stop using clindamycin and tretinoin and call your doctor right away if your skin becomes very red, swollen, blistered, or crusted.

clindamycin and tretinoin may also cause a temporary change in skin color (lighter or darker). Talk to your doctor if this concerns you.

Tell your doctor if you are planning to have a surgery before using clindamycin and tretinoin. clindamycin and tretinoin may affect how certain anesthesia medicines (medicines used during surgery to make you numb) work.

Do not use any other medicines on the treated skin areas without asking your doctor. Avoid using any skin care products that can dry or irritate your skin. These include rough skin cleansers, soaps, or products that contain alcohol, spices, or lime.

clindamycin and tretinoin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • itching
  • unusually warm skin
Less common
  • Burning or stinging at the site of application
  • changes in the color of the skin
  • fever
  • stomach cramps, tenderness, or pain
  • watery or bloody diarrhea

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cough
  • dry skin
  • headaches
  • muscle aches
  • pain and tenderness around the eyes and cheekbones
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest or wheezing
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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