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carisoprodol, aspirin, and codeine (Oral route)

kar-eye-soe-PROE-dol, AS-pir-in, KOE-deen

Pharmacologic Class: NSAID

Chemical Class: Salicylate, Aspirin

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Uses For carisoprodol, aspirin, and codeine

Carisoprodol, aspirin, and codeine combination is used to relax certain muscles in your body and relieve the discomfort caused by acute (short-term), painful muscle or bone conditions. However, carisoprodol, aspirin, and codeine does not take the place of rest, exercise, physical therapy, or other treatments that your doctor may recommend for your medical condition.

Carisoprodol is a skeletal muscle relaxant. It acts on the central nervous system (CNS) to relax muscles. Aspirin is an antiinflammatory agent that is often used for pain and fever. Codeine is a narcotic analgesic (pain medicine) that acts on the CNS to relieve pain.

carisoprodol, aspirin, and codeine is available only with your doctor's prescription.

Before Using carisoprodol, aspirin, and codeine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For carisoprodol, aspirin, and codeine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to carisoprodol, aspirin, and codeine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of carisoprodol, aspirin, and codeine combination in children below 12 years of age. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of carisoprodol, aspirin, and codeine combination in geriatric patients. However, elderly patients are more likely to have age-related kidney or liver problems, which may require caution in patients receiving carisoprodol, aspirin, and codeine combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Aspirin

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Carisoprodol

Codeine

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Using carisoprodol, aspirin, and codeine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ketorolac
Naltrexone

Using carisoprodol, aspirin, and codeine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol
Adinazolam
Alfentanil
Alprazolam
Amobarbital
Anileridine
Anisindione
Aprobarbital
Beta Glucan
Bromazepam
Brotizolam
Buprenorphine
Butabarbital
Butalbital
Butorphanol
Carisoprodol
Chloral Hydrate
Chlordiazepoxide
Chlorzoxazone
Citalopram
Clobazam
Clonazepam
Clorazepate
Clovoxamine
Codeine
Dantrolene
Desvenlafaxine
Dezocine
Diazepam
Dicumarol
Duloxetine
Eptifibatide
Escitalopram
Estazolam
Ethchlorvynol
Femoxetine
Fentanyl
Flesinoxan
Flunitrazepam
Fluoxetine
Flurazepam
Fluvoxamine
Ginkgo
Halazepam
Heparin
Hydrocodone
Hydromorphone
Ketazolam
Ketoprofen
Levorphanol
Lorazepam
Lormetazepam
Medazepam
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Methotrexate
Midazolam
Milnacipran
Morphine
Morphine Sulfate Liposome
Nalbuphine
Nefazodone
Nitrazepam
Nordazepam
Opium
Oxazepam
Oxycodone
Oxymorphone
Paroxetine
Pentazocine
Pentobarbital
Phenindione
Phenobarbital
Phenprocoumon
Prazepam
Primidone
Propoxyphene
Quazepam
Remifentanil
Reteplase, Recombinant
Secobarbital
Sertraline
Sodium Oxybate
Sufentanil
Tapentadol
Temazepam
Thiopental
Ticlopidine
Triazolam
Varicella Virus Vaccine
Venlafaxine
Warfarin
Zimeldine

Using carisoprodol, aspirin, and codeine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ardeparin
Betamethasone
Captopril
Celecoxib
Certoparin
Chlorpropamide
Cortisone
Dalteparin
Danaparoid
Deflazacort
Delapril
Dexamethasone
Diltiazem
Enalaprilat
Enalapril Maleate
Enoxaparin
Furosemide
Glyburide
Ibuprofen
Imidapril
Lisinopril
Methylprednisolone
Nadroparin
Nitroglycerin
Paramethasone
Parnaparin
Prednisolone
Prednisone
Probenecid
Reviparin
Rofecoxib
Streptokinase
Tamarind
Temocapril
Tenecteplase
Tinzaparin
Tirofiban
Tolbutamide
Triamcinolone
Valproic Acid
Verapamil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using carisoprodol, aspirin, and codeine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use carisoprodol, aspirin, and codeine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Proper Use of carisoprodol, aspirin, and codeine

Take carisoprodol, aspirin, and codeine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If codeine is taken regularly and in large amounts, it may become habit-forming (causing mental or physical dependence).

Dosing

The dose of carisoprodol, aspirin, and codeine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of carisoprodol, aspirin, and codeine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For relaxing muscles:
- For oral dosage form (tablets):
  - Adults and children 12 years of age and older—1 or 2 tablets four times a day.
  - Children below 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of carisoprodol, aspirin, and codeine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using carisoprodol, aspirin, and codeine

It is very important that your doctor check your progress at regular visits to make sure carisoprodol, aspirin, and codeine is working properly and to check for unwanted effects.

carisoprodol, aspirin, and codeine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to carisoprodol, aspirin, and codeine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

carisoprodol, aspirin, and codeine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking carisoprodol, aspirin, and codeine.

Do not stop using carisoprodol, aspirin, and codeine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

carisoprodol, aspirin, and codeine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning feeling in chest or stomach
indigestion
stomach upset
tenderness in stomach area

Less common

Cough
difficult or troubled breathing
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
noisy breathing
shakiness and unsteady walk
shortness of breath
tightness in chest
unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known

Chills
cold sweats
confusion
continuing ringing or buzzing or other unexplained noise in ears
difficulty swallowing
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fast, pounding, or irregular heartbeat or pulse
flushing or redness of skin
hearing loss
hives
itching
painful or difficult urination
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
skin rash
sore throat
sores, ulcers, or white spots on lips or in mouth
swollen glands
unusual bleeding or bruising
unusual tiredness or weakness
unusually warm skin
wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation or combativeness
anxiety
black, tarry stools
bloody stools
blue lips and fingernails
change in consciousness
cold, clammy skin
confusion
confusion as to time, place, or person
coughing that sometimes produces a pink frothy sputum
decreased awareness or responsiveness
decreased urination
depression
diarrhea
difficult, fast, noisy breathing, sometimes with wheezing
difficulty sleeping
disorientation
drowsiness to profound coma
dry mouth
expressed fear of impending death
extremely high fever or body temperature
fainting
fast or deep breathing
fast, weak pulse
hallucinations
headache
holding false beliefs that cannot be changed by fact
irregular, fast or slow, or shallow breathing
lethargy
loss of consciousness
loss of strength or energy
mood or other mental changes
muscle cramps
muscle pain or weakness
nausea
pale or blue lips, fingernails, or skin
pale, clammy skin
pinpoint pupils
severe sleepiness
sunken eyes
sweating
swelling in legs and ankles
thirst
unusual excitement, nervousness, or restlessness
vomiting
vomiting of blood or material that looks like coffee grounds
wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

Less common

Feeling of constant movement of self or surroundings
sensation of spinning

Rare

Hyperventilation
irritability
shaking
sleeplessness
trouble sleeping
unable to sleep

Incidence not known

Constipation
constricted, pinpoint, or small pupils (black part of eye)
relaxed and calm

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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