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capreomycin (Injection route)

kap-ree-oh-MYE-sin

Injection route(Powder for Solution)

Use capreomycin in patients with renal insufficiency or preexisting auditory impairment with great caution, and the risk of additional auditory impairment or renal injury should be weighed against the benefits to be derived from therapy. Simultaneous administration of other parenteral antituberculosis agents which have similar and sometimes irreversible toxic effects, particularly on auditory and renal function, is not recommended. Use with nonantituberculosis drugs having ototoxic or nephrotoxic potential should be undertaken only with great caution. The safety of capreomycin in pregnancy and in pediatric patients has not been established .

Commonly used brand name(s)

In the U.S.

  • Capastat Sulfate

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antitubercular

Chemical Class: Aminoglycoside

Uses For capreomycin

Capreomycin is used to treat tuberculosis (TB). It is given with other medicines for TB.

To help clear up your tuberculosis (TB) completely, you must keep taking capreomycin for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

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Capreomycin is available only with your doctor's prescription.

Before Using capreomycin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For capreomycin, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to capreomycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on capreomycin have been done only in adult patients, and there is no specific information comparing use of capreomycin in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of capreomycin in the elderly with use in other age groups.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving capreomycin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using capreomycin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine

Using capreomycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Colistimethate Sodium

Using capreomycin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alcuronium
  • Atracurium
  • Cisatracurium
  • Doxacurium
  • Fazadinium
  • Gallamine
  • Hexafluorenium
  • Metocurine
  • Mivacurium
  • Pancuronium
  • Pipecuronium
  • Rapacuronium
  • Rocuronium
  • Tubocurarine
  • Vecuronium

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of capreomycin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Eighth-cranial-nerve disease (loss of hearing and/or balance)—Capreomycin may cause hearing and balance side effects
  • Kidney disease—Capreomycin may cause serious side effects affecting the kidneys
  • Myasthenia gravis or
  • Parkinson's disease—Capreomycin may cause muscular weakness

Proper Use of capreomycin

To help clear up your infection completely, it is very important that you keep taking capreomycin for the full time of treatment, even if you begin to feel better after a few weeks. You may have to use it every day for as long as 1 to 2 years or more. If you stop using capreomycin too soon, your symptoms may return.

Dosing

The dose of capreomycin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of capreomycin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For treatment of tuberculosis (TB):
      • Adults and adolescents—1 gram of capreomycin injected into the muscle once a day for 60 to 120 days. After this time, 1 gram of capreomycin is injected into the muscle 2 or 3 times a week. capreomycin must be given with other medicines to treat tuberculosis (TB).
      • Children—Dose has not been determined.

capreomycin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Greatly increased or decreased frequency of urination or amount of urine
  • increased thirst
  • loss of appetite
  • nausea
  • vomiting
Less common
  • Any loss of hearing
  • clumsiness or unsteadiness
  • difficulty in breathing
  • dizziness
  • drowsiness
  • fever
  • irregular heartbeat
  • itching
  • muscle cramps or pain
  • pain, redness, hardness, unusual bleeding, or a sore at the place of injection
  • ringing or buzzing or a feeling of fullness in the ears
  • skin rash
  • swelling
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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