asparaginase (Injection route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Asparaginase (class)
Uses For asparaginase
Asparaginase injection is used together with other medicines to treat acute lymphoblastic leukemia (ALL), a cancer of the blood.
Asparaginase belongs to the group of medicines known as enzymes. All cells need a chemical called asparagine to stay alive. Normal cells can make this chemical, but cancer cells cannot. Asparaginase breaks down asparagine in the body. Since the cancer cells cannot make more asparagine, they die.
asparaginase is to be given only by or under the immediate supervision of your doctor.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, asparaginase is used in certain patients with the following condition:
- Acute myeloid leukemia (cancer of the blood).
Before Using asparaginase
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For asparaginase, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to asparaginase or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of asparaginase injection in children.
Although appropriate studies on the relationship of age to the effects of asparaginase injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving asparaginase, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using asparaginase with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Rotavirus Vaccine, Live
Using asparaginase with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Adenovirus Vaccine Type 4, Live
- Adenovirus Vaccine Type 7, Live
- Bacillus of Calmette and Guerin Vaccine, Live
- Influenza Virus Vaccine, Live
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Vaccine
- Typhoid Vaccine
- Varicella Virus Vaccine
- Vincristine Sulfate Liposome
- Yellow Fever Vaccine
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of asparaginase. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Blood clotting problems or
- Diabetes or
- Hyperglycemia (high blood sugar) or
- Liver disease or
- Pancreatitis (inflamed pancreas)—Use with caution. May make these conditions worse.
- Bleeding problems due to asparaginase, history of or
- Blood clotting problems due to asparaginase, history of or
- Pancreatitis (inflamed pancreas) due to asparaginase, history of—Should not be given to patients with these conditions.
Proper Use of asparaginase
A doctor or other trained health professional will give you asparaginase in a hospital or cancer treatment center. asparaginase is given as a shot into one of your muscles or into your vein.
asparaginase is usually given together with other medicines. If you are taking some of these medicines by mouth, make sure you take them at the right times.
asparaginase needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Precautions While Using asparaginase
It is very important that your doctor check your progress at regular visits to make sure asparaginase is working properly. Blood tests may be needed to check for unwanted effects.
asparaginase may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have chills, a fever, lightheadedness, dizziness, or fainting, a fast, pounding heartbeat, swelling of the face, tongue, and throat, or trouble breathing after you receive the medicine.
Tell your doctor right away if you have confusion, headaches, nausea and vomiting, numbness or tingling in the arms or legs, shortness of breath, or chest pain after receiving asparaginase. These may be symptoms of a serious bleeding or blood clotting problem.
Pancreatitis may occur while you are receiving asparaginase. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
Check with your doctor right away if you have increased thirst or hunger, increased urination, pale skin, nausea, sweating, or faintness. These may be symptoms of hyperglycemia (high blood sugar).
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Elspar® may cause a condition called posterior reversible encephalopathy syndrome (PRES) when used with other cancer medicines. Check with your doctor right away if you have headaches, confusion, seizures, blurred vision or changes in vision, dizziness, or a fast, slow, or pounding heartbeat.
asparaginase Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:More common
- Abdominal or stomach pain
- blurred vision
- darkened urine
- difficulty with swallowing
- dry mouth
- fast heartbeat
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- joint pain
- loss of appetite
- pains in the chest, groin, or legs, especially calves of the legs
- pains in the stomach, side, or abdomen, possibly radiating to the back
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- skin rash
- stomach pain (severe) with nausea and vomiting
- sudden loss of coordination
- sudden onset of severe headaches
- sudden onset of slurred speech
- sudden vision changes
- tightness in the chest
- troubled breathing
- unexplained weight loss
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
- convulsions (seizures)
- frequent urination
- loss of bladder control
- lower back or side pain
- muscle spasm or jerking of all extremities
- numbness or tingling in the hands, arms, or legs
- seeing, hearing, or feeling things that are not there
- severe weakness
- sores in the mouth or on the lips
- sudden loss of consciousness
- swelling of the feet or lower legs
- unusual thirst
- Inability to move the arms or legs
- Abdominal or stomach tenderness
- bloody or cloudy urine
- change in consciousness
- clay-colored stools
- continuous nausea or vomiting
- loss of consciousness
- pounding in the ears
- slow heartbeat
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Stomach cramps
- weight loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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- Other brands: Elspar