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amphotericin b cholesteryl sulfate complex (Intravenous route)

am-foe-TER-i-sin B koe-les-TEER-il SUL-fate KOM-plex

Commonly used brand name(s)

In the U.S.

  • Amphotec

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antifungal

Chemical Class: Polyene

Uses For amphotericin b cholesteryl sulfate complex

Amphotericin B cholesteryl complex is an antifungal medicine. It is used to help the body overcome serious infections, such as aspergillosis, that are caused by fungus.

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amphotericin b cholesteryl sulfate complex is available only with your doctor's prescription.

Before Using amphotericin b cholesteryl sulfate complex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amphotericin b cholesteryl sulfate complex, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to amphotericin b cholesteryl sulfate complex or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

amphotericin b cholesteryl sulfate complex has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

amphotericin b cholesteryl sulfate complex has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking amphotericin b cholesteryl sulfate complex, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using amphotericin b cholesteryl sulfate complex with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of amphotericin B cholesteryl complex. Make sure you tell your doctor if you have any other medical problems.

Proper Use of amphotericin b cholesteryl sulfate complex

Dosing

The dose of amphotericin b cholesteryl sulfate complex will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of amphotericin b cholesteryl sulfate complex. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For treatment of aspergillosis:
      • Adults and children—3 to 4 milligrams per kilogram (1.36 to 1.81 mg per pound) of body weight, injected slowly into a vein, once a day.

amphotericin b cholesteryl sulfate complex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Chills
  • fever
  • headache
  • nausea
Less common
  • Difficulty in breathing
  • dizziness or fainting
  • increased heartbeat
  • unusual bleeding or bruising
Rare
  • Difficulty in swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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