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Medications for Restless Legs Syndrome

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Parcopa Off-label Rate Add review
Rx C N X
Generic name:
carbidopa / levodopa systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
levodopa 8.0 1 review for levodopa to treat Restless Legs Syndrome
Rx N N X
Generic name:
levodopa systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
gabapentin enacarbil 7.0 34 reviews for gabapentin enacarbil to treat Restless Legs Syndrome
Rx C N X
Generic name:
gabapentin enacarbil systemic
Brand name:
Horizant
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
lamotrigine Off-label 5.5 2 reviews for lamotrigine to treat Restless Legs Syndrome
Rx C N X
Generic name:
lamotrigine systemic
Drug class:
triazine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
clonidine Off-label 7.7 7 reviews for clonidine to treat Restless Legs Syndrome
Rx C N X
Generic name:
clonidine systemic
Drug class:
antiadrenergic agents, centrally acting
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Horizant 7.2 30 reviews for Horizant to treat Restless Legs Syndrome
Rx C N X
Generic name:
gabapentin enacarbil systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
rotigotine 8.1 48 reviews for rotigotine to treat Restless Legs Syndrome
Rx C N X
Generic name:
rotigotine systemic
Brand name:
Neupro
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
pregabalin Off-label 6.9 15 reviews for pregabalin to treat Restless Legs Syndrome
Rx C 5 X
Generic name:
pregabalin systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
carbidopa / levodopa Off-label 8.4 36 reviews for carbidopa / levodopa to treat Restless Legs Syndrome
Rx C N X
Generic name:
carbidopa / levodopa systemic
Brand names:
Sinemet, Parcopa
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Sinemet Off-label 7.9 18 reviews for Sinemet to treat Restless Legs Syndrome
Rx C N X
Generic name:
carbidopa / levodopa systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Neupro 8.0 46 reviews for Neupro to treat Restless Legs Syndrome
Rx C N X
Generic name:
rotigotine systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
tramadol Off-label 8.8 131 reviews for tramadol to treat Restless Legs Syndrome
Rx C 4 X
Generic name:
tramadol systemic
Drug class:
Opioids (narcotic analgesics)
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
clonazepam Off-label 8.1 96 reviews for clonazepam to treat Restless Legs Syndrome
Rx D 4 X
Generic name:
clonazepam systemic
Drug class:
benzodiazepines, benzodiazepine anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
gabapentin Off-label 7.5 125 reviews for gabapentin to treat Restless Legs Syndrome
Rx C N X
Generic name:
gabapentin systemic
Drug class:
gamma-aminobutyric acid analogs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
pramipexole 6.9 201 reviews for pramipexole to treat Restless Legs Syndrome
Rx C N X
Generic name:
pramipexole systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
ropinirole 6.6 289 reviews for ropinirole to treat Restless Legs Syndrome
Rx C N X
Generic name:
ropinirole systemic
Drug class:
dopaminergic antiparkinsonism agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information

Frequently asked questions

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Topics under Restless Legs Syndrome

Learn more about Restless Legs Syndrome

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.