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Migraine Medications Compared

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
amitriptyline Rate Add review
Rx C N X
Generic name:
amitriptyline systemic
Drug class:
tricyclic antidepressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Anacin Advanced Headache Formula Rate Add review
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
atogepant Rate Add review
Rx N
Generic name:
atogepant systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Backaid Inflammatory Pain Formula Rate Add review
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
Elyxyb Rate Add review
Rx C N
Generic name:
celecoxib systemic
Drug class:
cox-2 inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
eptinezumab Rate Add review
Rx N
Generic name:
eptinezumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
erenumab Rate Add review
Rx N
Generic name:
erenumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Fortabs Rate Add review
Rx C 3 X
Generic name:
aspirin / butalbital / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
fremanezumab Rate Add review
Rx N
Generic name:
fremanezumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
galcanezumab Rate Add review
Rx N
Generic name:
galcanezumab systemic
Drug class:
CGRP inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Genace Rate Add review
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
ibuprofen Rate Add review
Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Migraine Relief Rate Add review
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
RizaFilm Rate Add review
Rx C N
Generic name:
rizatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
timolol Rate Add review
Rx C N X
Generic name:
timolol systemic
Drug class:
non-cardioselective beta blockers
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
topiramate Rate Add review
Rx D N X
Generic name:
topiramate systemic
Drug class:
carbonic anhydrase inhibitor anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Tosymra Rate Add review
Rx C N
Generic name:
sumatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
valproic acid Rate Add review
Rx D N X
Generic name:
valproic acid systemic
Drug class:
fatty acid derivative anticonvulsants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
verapamil Rate Add review
Rx C N X
Generic name:
verapamil systemic
Drug class:
calcium channel blocking agents, group IV antiarrhythmics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Zembrace SymTouch Rate Add review
Rx C N
Generic name:
sumatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
prochlorperazine Off-label 1.0 1 review for prochlorperazine to treat Migraine
Rx/OTC N N X
Generic name:
prochlorperazine systemic
Drug class:
phenothiazine antiemetics, phenothiazine antipsychotics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Reglan 2.9 135 reviews for Reglan to treat Migraine
Rx B N X
Generic name:
metoclopramide systemic
Drug class:
GI stimulants, miscellaneous antiemetics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
metoclopramide 3.4 193 reviews for metoclopramide to treat Migraine
Rx B N X
Generic name:
metoclopramide systemic
Brand name:
Reglan
Drug class:
GI stimulants, miscellaneous antiemetics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Reyvow 4.4 22 reviews for Reyvow to treat Migraine
Rx 5
Generic name:
lasmiditan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
lasmiditan 4.6 26 reviews for lasmiditan to treat Migraine
Rx 5
Generic name:
lasmiditan systemic
Brand name:
Reyvow
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph

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Topics under Migraine

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Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.